科学网—刊・见｜糖尿病/肥胖研究发哪里？这本代谢研究国际期刊是首选-Taylor&Francis学术服务的博文

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2026-7-3 15:12

| 个人分类: 医药健康 | 系统分类: 科研笔记

本期 【刊•见】 为诸位介绍一本内分泌学与代谢领域的国际期刊— Archives of Physiology and Biochemistry 。除了对关键指标进行详尽解读外，还向您推荐刊内近三年高被引文章，以及近一年高阅读量文章：

氧化应激在糖尿病并发症中的作用及抗氧化剂干预策略

探索植物源性α-葡萄糖苷酶抑制剂：对抗2型糖尿病的有前景候选药物

高血糖致心力衰竭：糖尿病心肌病的分子病理生理学、临床表现及新型治疗靶点

高住低训模式可提升 C57BL/6J 小鼠自发活动量、减少脂肪堆积并维持瘦体重

Online ISSN: 1744-4160 Print ISSN: 1381-3455

Archives of Physiology and Biochemistry 是一本跨学科期刊，旨在整合代谢领域的重要研究成果。本刊重点关注能量稳态调控方向，涵盖糖尿病、肥胖、血脂异常及心血管疾病等代谢性疾病的发病机制与潜在治疗方案。尤其优先发表能够从分子层面，深入阐释能量稳态及其功能异常相关生理学、生物化学机理的研究。

该期刊已被SCI、Scopus等核心数据库收录。

【期刊主页】👉 https://www.tandfonline.com/journals/IARP20

影响因子

根据JCR显示， Archives of Physiology and Biochemistry

在内分泌学与代谢病学排名 103/198

在生理学排名 27/89

Scopus

根据Scopus显示， Archives of Physiology and Biochemistry

2025年CiteScore为 8.7

2026年CiteScore Tracker为 7.1

在医学：生理学（医学方向）排名 17/117

在生物化学、遗传学与分子生物学：生理学排名 24/196

作者须知

接收文章类型

Archives of Physiology and Biochemistry 期刊大力鼓励投稿代谢研究领域中常被忽视的核心原理与理论基础。相关主题包括：假设驱动型研究、大数据技术、代谢疾病动物模型（含基因敲除小鼠模型）的优势、现存问题、替代方案及综合研究思路；知识的呈现与传播方式；以及推动科学发展的各类要素（如学术论文、科研基金等）。

文章出版费（APC）

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编辑团队

Archives of Physiology and Biochemistry 主编为澳大利亚悉尼大学医学院Dr. Melkam Kebede。期刊编委会由欧洲、澳洲、北美等多国专家组成，覆盖分子代谢、细胞生理、线粒体功能、脂肪 / 肝脏 / 骨骼肌代谢、心血管代谢、运动代谢、临床生化与转化医学等广泛领域。

主编

Dr. Melkam Kebede

任职于澳大利亚悉尼大学医学院，主攻胰岛生物学 和 2 型糖尿病，主要关注一下领域的研究和应用：

胰腺 β 细胞功能衰竭机制（2 型糖尿病发病核心）

胰岛素分泌颗粒（ISG）的生物发生、成熟、稳定性、靶向分泌

蛋白质组学、显微成像、细胞 / 动物模型在糖尿病研究中的应用

作者分布

根据JCR显示，近三年在 Archives of Physiology and Biochemistry 发文的国家/地区中，发文数量排名前三的有：

中国

伊朗

埃及

近三年，在 Archives of Physiology and Biochemistry 发文的全球高校和科研机构中，发文数量排名前三的是：

埃及知识库

土耳其伊诺努大学

巴西南大河州联邦大学

近三年内高被引文章

Role of oxidative stress in diabetes-induced complications and their management with antioxidants

氧化应激在糖尿病并发症中的作用及抗氧化剂干预策略

作者： Hasandeep Singh et al.

文章摘要：

Diabetes mellitus (DM) is a huge global health issue and one of the most studied diseases, with a large global prevalence. Oxidative stress is a cytotoxic consequence of the excessive development of ROS and suppression of the antioxidant defense system for ROS elimination, which accelerates the progression of diabetes complications such as diabetic neuropathy, retinopathy, and nephropathy. Hyperglycaemia induced oxidative stress causes the activation of seven major pathways implicated in the pathogenesis of diabetic complications. These pathways increase the production of ROS and RNS, which contributes to dysregulated autophagy, gene expression changes, and the development of numerous pro-inflammatory mediators which may eventually lead to diabetic complications. This review will illustrate that oxidative stress plays a vital role in the pathogenesis of diabetic complications, and the use of antioxidants will help to reduce oxidative stress and thus may alleviate diabetic complications.

Exploring plant-based alpha-glucosidase inhibitors: promising contenders for combatting type-2 diabetes

探索植物源性α-葡萄糖苷酶抑制剂：对抗2型糖尿病的有前景候选药物

作者： Sonali Kumari et al.

文章摘要：

Objective

This systematic review aimed to provide comprehensive details on the α-G inhibitory potential of various bioactive compounds derived from natural sources.

Methods

A comprehensive literature search was conducted using various databases and search engines, including Science Direct, Google Scholar, SciFinder, Web of Science, and PubMed until May, 2023. Results and conclusions

The enzyme alpha-glucosidase (α-G) is found in the brush border epithelium of the small intestine and consists of duplicated glycoside hydrolase (GH31) domain. It involves the conversion of disaccharides and oligosaccharides into monosaccharides by acting on alpha (1 → 4) and (1 → 6) linked glucose residue. Once absorbed, glucose enters the bloodstream and elevates postprandial glucose, which is associated with the development of type 2 Diabetes (T2D). Epidemic obesity, cardiovascular disease, and nephropathy are linked to T2D. Traditional medicinal plants with α-G inhibitory potential are commonly used to treat T2D due to the adverse effects of currently used α-G inhibitors miglitol, acarbose, and voglibose. Various bioactive compounds derived from natural sources, including lupenone, Wilforlide A, Baicalein, Betulinic acid, Ursolic acid, Oleanolic acid, Katononic acid, Carnosol, Hypericin, Astilbin, lupeol, betulonic acid, Fagomine, Lactucaxanthin, Erythritol, GP90-1B, Procyanidins, Galangin, and vomifoliol retain α-G inhibitory potential for regulating hyperglycaemia.

近一年内高阅读量文章

Hyperglycaemia to heart failure: molecular pathophysiology, clinical manifestations, and novel therapeutic targets for diabetic cardiomyopathy

高血糖致心力衰竭：糖尿病心肌病的分子病理生理学、临床表现及新型治疗靶点

作者： Bhagyalakshmi Balakrishnan et al.

文章摘要：

Objective

To provide a comprehensive review of the molecular and physiological mechanisms underlying diabetic cardiomyopathy, elucidating how metabolic dysregulation contributes to cardiac structural and functional alterations. This study also aims to highlight the potential therapeutic targets involved in the key signaling pathways of DCM pathogenesis.

Methods

A systematic literature review was conducted using major scientific databases, including PubMed, Scopus, and Web of Science, covering studies published between 2000 and 2025. Keywords used included “diabetic cardiomyopathy,” “hyperglycemia,” “insulin resistance,” “oxidative stress,” “inflammation,” “mitochondrial dysfunction,” and “therapeutic targets.”

Data Sources, Study Selection, and Data Extraction

Peer-reviewed articles, original research papers, and review articles focusing on molecular mechanisms, signaling pathways, and therapeutic interventions related to DCM were included. Studies involving both experimental models and human subjects were considered. Data were extracted regarding metabolic alterations, key signaling cascades (NF-κB, PARP1, GLUT4, AT1R), and their association with cardiac remodeling, fibrosis, and functional impairment. The information was synthesized to illustrate the progression from metabolic imbalance to clinical manifestations and to identify promising molecular targets for therapy.

SIGNIFICANCE STATEMENT

Diabetic Cardiomyopathy is a critical metabolic and cardiac disorder. The IDF Diabetic Atlas 2021 reported that 537 million people are living with diabetes in the world and will peak at 643 million by 2030 (Magliano & Boyko, 2021). It is startling that 12% of diabetic patients develop cardiomyopathy, and the cause of mortality is predominantly heart failure (Lorenzo-Almorós et al., Citation2017). The disease remains asymptomatic and, therefore, is not well diagnosed in earlier stages. There is an obvious lack of in-depth understanding of the mechanism and pathophysiology in this regard. Through our review, we try to understand the symptoms through the underlying mechanism of pathophysiology. We also review crucial potential therapeutic moieties like NFKB, PARP, AT1R, and GLUT4 for alleviating Diabetic Cardiomyopathy.

Living high-training low model promotes increased spontaneous physical activity, reduced adiposity and maintenance of fat-free mass in C57BL/6J mice

高住低训模式可提升 C57BL/6J 小鼠自发活动量、减少脂肪堆积并维持瘦体重

作者： Juan B. Orsi et al.

文章摘要：

Researchers have extensively studied how hypoxia affects physiological variables, with training models like “live high - train low” (LH-TL) proposed by Levine & Stray-Gundersen in 1997 to improve athletic performance. Although well-known, few studies use animal models for more in-depth analyses than human studies allow. This study investigated the effects of aerobic training on adiposity, spontaneous physical activity (SPA), and food and water intake in C57BL/6J mice housed in normoxic (Nx) or hypoxic (Hx) conditions for 8 weeks. Mice were divided into trained (T) and sedentary (S) groups, with 10 mice each. Hx animals were kept in normobaric hypoxia (FiO2=14.5%) for 18 h/day. Training was done at 80% critical velocity, 5 times/week in normoxia. The T groups had lower SPA, especially the Hx-T group, which showed higher food and water intake, reduced fat, and a higher fat-free mass/carcass fat mass ratio. Findings suggest exercise and hypoxia may help combat obesity.

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